The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choic...
The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining or homologous recombination (HR). Cell cycle stage and DNA end resection are believed to regulate the commitment to HR repair. Here we identify RNF138 as a ubiquitin E3 ligase that regulates the HR pathway. RNF138 is recruited to DNA damage sites through zinc fingers...
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The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice
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TN_cdi_proquest_miscellaneous_1773832426
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1773832426
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1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3259
