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Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/AL...

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/AL...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1773833735

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

About this item

Full title

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

Publisher

New York: Nature Publishing Group US

Journal title

Nature neuroscience, 2015-09, Vol.18 (9), p.1226-1229

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

C9orf72
mutations are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. With unbiased screens in
Saccharomyces cerevisiae
, Jovicic
et al
. identified potent modifiers of toxicity of dipeptide repeat proteins produced by unconventional translation of the
C9orf72
repeat expansions, pointing to n...

Alternative Titles

Full title

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1773833735

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1773833735

Other Identifiers

ISSN

1097-6256

E-ISSN

1546-1726

DOI

10.1038/nn.4085

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