TCR-induced sumoylation of the kinase PKC-[theta] controls T cell synapse organization and T cell ac...
TCR-induced sumoylation of the kinase PKC-[theta] controls T cell synapse organization and T cell activation
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New York: Nature Publishing Group
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English
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New York: Nature Publishing Group
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Sumoylation regulates many cellular processes, but its role in signaling via the T cell antigen receptor (TCR) remains unknown. We found that the kinase PKC-θ was sumoylated upon costimulation with antigen or via the TCR plus the coreceptor CD28, with Lys325 and Lys506 being the main sumoylation sites. We identified the SUMO E3 ligase PIASxβ as a l...
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Full title
TCR-induced sumoylation of the kinase PKC-[theta] controls T cell synapse organization and T cell activation
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TN_cdi_proquest_miscellaneous_1773834454
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1773834454
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.3259
