T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex
T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex
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Author / Creator
Beringer, Dennis X , Kleijwegt, Fleur S , Wiede, Florian , van der Slik, Arno R , Loh, Khai Lee , Petersen, Jan , Dudek, Nadine L , Duinkerken, Gaby , Laban, Sandra , Joosten, Antoinette , Vivian, Julian P , Chen, Zhenjun , Uldrich, Adam P , Godfrey, Dale I , McCluskey, James , Price, David A , Radford, Kristen J , Purcell, Anthony W , Nikolic, Tatjana , Reid, Hugh H , Tiganis, Tony , Roep, Bart O and Rossjohn, Jamie
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
To date, structural analysis has demonstrated a highly consistent binding pattern of the TCR to the MHC molecule. Rossjohn and colleagues reveal the first structures of two human T
reg
cell TCRs and show that they bind with a reversed polarity to the MHC.
Central to adaptive immunity is the interaction between the αβ T cell receptor (TCR)...
Alternative Titles
Full title
T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex
Authors, Artists and Contributors
Author / Creator
Kleijwegt, Fleur S
Wiede, Florian
van der Slik, Arno R
Loh, Khai Lee
Petersen, Jan
Dudek, Nadine L
Duinkerken, Gaby
Laban, Sandra
Joosten, Antoinette
Vivian, Julian P
Chen, Zhenjun
Uldrich, Adam P
Godfrey, Dale I
McCluskey, James
Price, David A
Radford, Kristen J
Purcell, Anthony W
Nikolic, Tatjana
Reid, Hugh H
Tiganis, Tony
Roep, Bart O
Rossjohn, Jamie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1773837899
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1773837899
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.3271
