Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27 super()Kip1 at G1 phase
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27 super()Kip1 at G1 phase
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Full title
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27 super()Kip1 at G1 phase
Author / Creator
Journal title
Nature cell biology, 2004-12, Vol.6 (12), p.1229-1235
Language
English
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Scope and Contents
Contents
The cyclin-dependent kinase inhibitor p27 super()Kip1 is degraded at the G0- G1 transition of the cell cycle by the ubiquitin-proteasome pathway. Although the nuclear ubiquitin ligase (E3) SCF super(Skp2) is implicated in p27 super()Kip1 degradation, proteolysis of p27 super()Kip1 at the G0-G1 transition proceeds normally in Skp2 super(-/-) cells....
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Full title
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27 super()Kip1 at G1 phase
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Record Identifier
TN_cdi_proquest_miscellaneous_17779440
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17779440
Other Identifiers
ISSN
1476-4679
DOI
10.1038/ncb1194
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