Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome
Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome
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Publisher
England
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Language
English
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England
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Contents
Chronic granulomatous disease (CGD) is caused by defects in nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) complex subunits (gp91(phox) (a.k.a. Nox2), p47(phox), p67(phox), p22(phox), p40(phox)) leading to reduced phagocyte-derived reactive oxygen species production. Almost half of patients with CGD develop inflammatory bowel disease,...
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Full title
Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome
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TN_cdi_proquest_miscellaneous_1779024461
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1779024461
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ISSN
2049-2618
E-ISSN
2049-2618
DOI
10.1186/s40168-016-0159-0