Post-translational modification of p53 in tumorigenesis
Post-translational modification of p53 in tumorigenesis
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Key Points
When a cell is confronted by stress, p53 is stabilized in the nucleus, where it initiates cellular responses through transcriptional activation or repression of distinct target genes that primarily function to prevent proliferation of damaged cells.
The function of p53 is tightly controlled by its interaction with negative regulato...
Alternative Titles
Full title
Post-translational modification of p53 in tumorigenesis
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TN_cdi_proquest_miscellaneous_17798427
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17798427
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ISSN
1474-175X
E-ISSN
1474-1768
DOI
10.1038/nrc1455
