Barrier regulation: tolerance stops at cell death
Barrier regulation: tolerance stops at cell death
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Author / Creator
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The accumulation of intestinal Foxp3
+
regulatory T cells (T
reg
cells) in response to the microbiota is tightly regulated. Epithelial apoptosis inhibits the production of tolerogenic interferon-β by myeloid cells and thereby reduces the frequency of T
reg
cells and lowers the threshold for inflammatory responses.
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Full title
Barrier regulation: tolerance stops at cell death
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TN_cdi_proquest_miscellaneous_1787960954
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1787960954
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.3418