Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracell...
Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra
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England
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English
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England
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ObjectivesIn the present study, we generated a new protein, recombinant human alpha-1-anti-trypsin (AAT)-IgG1 Fc fusion protein (AAT-Fc), and evaluated its properties to suppress inflammation and interleukin (IL)-1β in a mouse model of gouty arthritis.MethodsA combination of monosodium urate (MSU) crystals and the fatty acid C16.0 (MSU/C16.0) was i...
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Full title
Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra
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TN_cdi_proquest_miscellaneous_1788537263
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1788537263
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ISSN
0003-4967
E-ISSN
1468-2060
DOI
10.1136/annrheumdis-2014-206966
