The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
Macrophages accumulate with glioblastoma multiforme (GBM) progression and can be targeted via inhibition of colony-stimulating factor-1 receptor (CSF-1R) to regress high-grade tumors in animal models of this cancer. However, whether and how resistance emerges in response to sustained CSF-1R blockade is unknown. We show that although overall surviva...
Alternative Titles
Full title
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
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TN_cdi_proquest_miscellaneous_1790463125
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1790463125
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aad3018
