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A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy

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A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1792370594

A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy

About this item

Full title

A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy

Author / Creator

Huang, Lulin , Zhang, Houbin , Cheng, Ching-Yu , Wen, Feng , Tam, Pancy O S , Zhao, Peiquan , Chen, Haoyu , Li, Zheng , Chen, Lijia , Tai, Zhengfu , Yamashiro, Kenji , Deng, Shaoping , Zhu, Xianjun , Chen, Weiqi , Cai, Li , Lu, Fang , Li, Yuanfeng , Cheung, Chui-Ming G , Shi, Yi , Miyake, Masahiro , Lin, Yin , Gong, Bo , Liu, Xiaoqi , Sim, Kar-Seng , Yang, Jiyun , Mori, Keisuke , Zhang, Xiongzhe , Cackett, Peter D , Tsujikawa, Motokazu , Nishida, Kohji , Hao, Fang , Ma, Shi , Lin, He , Cheng, Jing , Fei, Ping , Lai, Timothy Y Y , Tang, Sibo , Laude, Augustinus , Inoue, Satoshi , Yeo, Ian Y , Sakurada, Yoichi , Zhou, Yu , Iijima, Hiroyuki , Honda, Shigeru , Lei, Chuntao , Zhang, Lin , Zheng, Hong , Jiang, Dan , Zhu, Xiong , Wong, Tien-Ying , Khor, Chiea-Chuen , Pang, Chi-Pui , Yoshimura, Nagahisa and Yang, Zhenglin

Publisher

New York: Nature Publishing Group US

Journal title

Nature genetics, 2016-06, Vol.48 (6), p.640-647

Language

English

Formats

Articles

Publication information

Publisher

New York: Nature Publishing Group US

Subjects

More information

Scope and Contents

Contents

Zhenglin Yang and colleagues use whole-exome sequencing to identify a rare variant in the
FGD6
gene that is associated with the polypoidal choroidal vasculopathy subtype of wet age-related macular degeneration. They show that FGD6 regulates proangiogenic effects together with VEGF and that the mutation results in abnormal retinal vessel devel...

Alternative Titles

Full title

A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1792370594

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1792370594

Other Identifiers

ISSN

1061-4036

E-ISSN

1546-1718

DOI

10.1038/ng.3546

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