Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors
About this item
Full title
Author / Creator
Jia, Yong , Yun, Cai-Hong , Park, Eunyoung , Ercan, Dalia , Manuia, Mari , Juarez, Jose , Xu, Chunxiao , Rhee, Kevin , Chen, Ting , Zhang, Haikuo , Palakurthi, Sangeetha , Jang, Jaebong , Lelais, Gerald , DiDonato, Michael , Bursulaya, Badry , Michellys, Pierre-Yves , Epple, Robert , Marsilje, Thomas H. , McNeill, Matthew , Lu, Wenshuo , Harris, Jennifer , Bender, Steven , Wong, Kwok-Kin , Jänne, Pasi A. and Eck, Michael J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
An allosteric inhibitor, EAI045, is reported that is selective for certain drug-resistant EGFR mutants, but spares the wild-type receptor; combination therapy of EAI045 with EGFR-dimerization-blocking antibodies is effective in mouse models of lung cancer driven by mutant versions of EGFR that are resistant to all previously developed inhibitors.
Alternative Titles
Full title
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors
Authors, Artists and Contributors
Author / Creator
Yun, Cai-Hong
Park, Eunyoung
Ercan, Dalia
Manuia, Mari
Juarez, Jose
Xu, Chunxiao
Rhee, Kevin
Chen, Ting
Zhang, Haikuo
Palakurthi, Sangeetha
Jang, Jaebong
Lelais, Gerald
DiDonato, Michael
Bursulaya, Badry
Michellys, Pierre-Yves
Epple, Robert
Marsilje, Thomas H.
McNeill, Matthew
Lu, Wenshuo
Harris, Jennifer
Bender, Steven
Wong, Kwok-Kin
Jänne, Pasi A.
Eck, Michael J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1793901045
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1793901045
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature17960
