Forebrain Degeneration and Ventricle Enlargement Caused by Double Knockout of Alzheimer's presenilin...
Forebrain Degeneration and Ventricle Enlargement Caused by Double Knockout of Alzheimer's presenilin-1 and presenilin-2
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Early-onset familial Alzheimer's disease is the most aggressive form of Alzheimer's, striking patients as early as their 30s; those patients typically carry mutations in presenilin-1 and presenilin-2. To investigate the coordinated functions of presenilin in the adult brain, we generated double knockout mice, in which both presenilins were deleted...
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Full title
Forebrain Degeneration and Ventricle Enlargement Caused by Double Knockout of Alzheimer's presenilin-1 and presenilin-2
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TN_cdi_proquest_miscellaneous_17977023
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17977023
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0402733101
