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Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

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Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1797872662

Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

About this item

Full title

Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

Author / Creator

Kataoka, Keisuke , Shiraishi, Yuichi , Takeda, Yohei , Sakata, Seiji , Matsumoto, Misako , Nagano, Seiji , Maeda, Takuya , Nagata, Yasunobu , Kitanaka, Akira , Mizuno, Seiya , Tanaka, Hiroko , Chiba, Kenichi , Ito, Satoshi , Watatani, Yosaku , Kakiuchi, Nobuyuki , Suzuki, Hiromichi , Yoshizato, Tetsuichi , Yoshida, Kenichi , Sanada, Masashi , Itonaga, Hidehiro , Imaizumi, Yoshitaka , Totoki, Yasushi , Munakata, Wataru , Nakamura, Hiromi , Hama, Natsuko , Shide, Kotaro , Kubuki, Yoko , Hidaka, Tomonori , Kameda, Takuro , Masuda, Kyoko , Minato, Nagahiro , Kashiwase, Koichi , Izutsu, Koji , Takaori-Kondo, Akifumi , Miyazaki, Yasushi , Takahashi, Satoru , Shibata, Tatsuhiro , Kawamoto, Hiroshi , Akatsuka, Yoshiki , Shimoda, Kazuya , Takeuchi, Kengo , Seya, Tsukasa , Miyano, Satoru and Ogawa, Seishi

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2016-06, Vol.534 (7607), p.402-406

Language

English

Formats

Articles

Publication information

Publisher

London: Nature Publishing Group UK

Subjects

Subjects and topics

More information

Scope and Contents

Contents

Structural variations disrupting the 3′ region of
PD-L1
are shown to aid immune evasion in a number of human cancers, including adult T-cell leukaemia/lymphoma, and in a mouse tumour model, CRISPR/Cas9-mediated deletion of the 3'-UTR of
Pd-l1
is also shown to result in immune escape, suggesting that
PD-L1
3′-UTR disruption could p...

Alternative Titles

Full title

Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1797872662

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1797872662

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature18294

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