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Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1797872686

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

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Publication information

Publisher

London: Nature Publishing Group UK

Subjects

Subjects and topics

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Scope and Contents

Contents

The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen-specific immunity in mouse tumour models; initial results in advanced melanoma patients indicate potential efficacy in humans.
An anti-cancer nanoparti...

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Full title

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

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Record Identifier

TN_cdi_proquest_miscellaneous_1797872686

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1797872686

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature18300

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