Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
About this item
Full title
Author / Creator
Kranz, Lena M. , Diken, Mustafa , Haas, Heinrich , Kreiter, Sebastian , Loquai, Carmen , Reuter, Kerstin C. , Meng, Martin , Fritz, Daniel , Vascotto, Fulvia , Hefesha, Hossam , Grunwitz, Christian , Vormehr, Mathias , Hüsemann, Yves , Selmi, Abderraouf , Kuhn, Andreas N. , Buck, Janina , Derhovanessian, Evelyna , Rae, Richard , Attig, Sebastian , Diekmann, Jan , Jabulowsky, Robert A. , Heesch, Sandra , Hassel, Jessica , Langguth, Peter , Grabbe, Stephan , Huber, Christoph , Türeci, Özlem and Sahin, Ugur
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen-specific immunity in mouse tumour models; initial results in advanced melanoma patients indicate potential efficacy in humans.
An anti-cancer nanoparti...
Alternative Titles
Full title
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
Authors, Artists and Contributors
Author / Creator
Diken, Mustafa
Haas, Heinrich
Kreiter, Sebastian
Loquai, Carmen
Reuter, Kerstin C.
Meng, Martin
Fritz, Daniel
Vascotto, Fulvia
Hefesha, Hossam
Grunwitz, Christian
Vormehr, Mathias
Hüsemann, Yves
Selmi, Abderraouf
Kuhn, Andreas N.
Buck, Janina
Derhovanessian, Evelyna
Rae, Richard
Attig, Sebastian
Diekmann, Jan
Jabulowsky, Robert A.
Heesch, Sandra
Hassel, Jessica
Langguth, Peter
Grabbe, Stephan
Huber, Christoph
Türeci, Özlem
Sahin, Ugur
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1797872686
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1797872686
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature18300