Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Excessive poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation kills cells via a cell-death process designated “parthanatos” in which PAR induces the mitochondrial release and nuclear translocation of apoptosis-inducing factor to initiate chromatinolysis and cell death. Accompanying the formation of PAR are the reduction of cellular NAD ⁺ and en...
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Full title
Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
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TN_cdi_proquest_miscellaneous_1803079208
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1803079208
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1405158111
