Heme impairs the ball-and-chain inactivation of potassium channels
Heme impairs the ball-and-chain inactivation of potassium channels
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Fine-tuned regulation of K ⁺ channel inactivation enables excitable cells to adjust action potential firing. Fast inactivation present in some K ⁺ channels is mediated by the distal N-terminal structure (ball) occluding the ion permeation pathway. Here we show that Kv1.4 K ⁺ channels are potently regulated by intracellular free heme; heme binds to...
Alternative Titles
Full title
Heme impairs the ball-and-chain inactivation of potassium channels
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Record Identifier
TN_cdi_proquest_miscellaneous_1803085167
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1803085167
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1313247110
