Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes
Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes
About this item
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Mitochondrial compromise is a fundamental contributor to pancreatic β-cell failure in diabetes. Previous studies have demonstrated a broader role for tumor suppressor p53 that extends to the modulation of mitochondrial homeostasis. However, the role of islet p53 in glucose homeostasis has not yet been evaluated. Here we show that p53 deficiency pro...
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Full title
Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes
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Record Identifier
TN_cdi_proquest_miscellaneous_1803086102
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1803086102
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1318951111
