NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interac...
NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
To subvert host immunity, influenza A virus (IAV) induces early apoptosis in innate immune cells by disrupting mitochondria membrane potential via its polymerase basic protein 1-frame 2 (PB1-F2) accessory protein. Whether immune cells have mechanisms to counteract PB1-F2–mediated apoptosis is currently unknown. Herein, we define that the host mitoc...
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Full title
NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein
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TN_cdi_proquest_miscellaneous_1803099227
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1803099227
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1322118111
