Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 f...
Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Significance Interleukin-1 family members are highly inflammatory but IL-37 member broadly suppresses inflammation and specific immunity. Initially, the mechanism of this suppression was shown to be via translocation to the nucleus following cleavage of the precursor by intracellular caspase-1. We now show that recombinant forms of IL-37 limit infl...
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Full title
Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8
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TN_cdi_proquest_miscellaneous_1803114826
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1803114826
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1424626112
