Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNO...
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The role of NF-κB activation in tumor initiation has not been thoroughly investigated. We generated Ikkβ(EE) ᴵᴱC transgenic mice expressing constitutively active IκB kinase β (IKKβ) in intestinal epithelial cells (IECs). Despite absence of destructive colonic inflammation, Ikkβ(EE) ᴵᴱC mice developed intestinal tumors after a long latency. However,...
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Full title
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation
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TN_cdi_proquest_miscellaneous_1803137878
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1803137878
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1211509109
