Pore-forming activity and structural autoinhibition of the gasdermin family
Pore-forming activity and structural autoinhibition of the gasdermin family
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Full title
Author / Creator
Ding, Jingjin , Wang, Kun , Liu, Wang , She, Yang , Sun, Qi , Shi, Jianjin , Sun, Hanzi , Wang, Da-Cheng and Shao, Feng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Inflammatory caspases cleave the gasdermin D (GSDMD) protein to trigger pyroptosis, a lytic form of cell death that is crucial for immune defences and diseases. GSDMD contains a functionally important gasdermin-N domain that is shared in the gasdermin family. The functional mechanism of action of gasdermin proteins is unknown. Here we show that the...
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Full title
Pore-forming activity and structural autoinhibition of the gasdermin family
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Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_1804854341
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1804854341
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature18590
