LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption
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Luo, Jian , Yang, Zhengfeng , Ma, Yu , Yue, Zhiying , Lin, Hongyu , Qu, Guojun , Huang, Jinping , Dai, Wentao , Li, Chenghai , Zheng, Chunbing , Xu, Leqin , Chen, Huaqing , Wang, Jiqiu , Li, Dali , Siwko, Stefan , Penninger, Josef M , Ning, Guang , Xiao, Jianru and Liu, Mingyao
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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LGR4 has been identified as a new receptor for RANKL in bone cells where it opposes RANK signaling to inhibit osteoclasts differentiation, and its therapeutic targeting promotes reduced bone loss in three mouse models of osteoporosis.
Tumor necrosis factor (TNF) superfamily member 11 (TNFSF11, also known as RANKL) regulates multiple physiologica...
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Full title
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption
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TN_cdi_proquest_miscellaneous_1805506541
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1805506541
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4076
