A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resis...
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance
About this item
Full title
Author / Creator
Jang, Cholsoon , Oh, Sungwhan F , Wada, Shogo , Rowe, Glenn C , Liu, Laura , Chan, Mun Chun , Rhee, James , Hoshino, Atsushi , Kim, Boa , Ibrahim, Ayon , Baca, Luisa G , Kim, Esl , Ghosh, Chandra C , Parikh, Samir M , Jiang, Aihua , Chu, Qingwei , Forman, Daniel E , Lecker, Stewart H , Krishnaiah, Saikumari , Rabinowitz, Joshua D , Weljie, Aalim M , Baur, Joseph A , Kasper, Dennis L and Arany, Zoltan
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Fatty acid transport from blood vessels to skeletal muscle, across endothelial cells, is regulated by the branched chain amino acid metabolite 3-hydroxy-isobutyrate. This finding provides a mechanistic explanation for the link between high levels of branched chain amino acids and diabetes.
Epidemiological and experimental data implicate branched...
Alternative Titles
Full title
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance
Authors, Artists and Contributors
Author / Creator
Oh, Sungwhan F
Wada, Shogo
Rowe, Glenn C
Liu, Laura
Chan, Mun Chun
Rhee, James
Hoshino, Atsushi
Kim, Boa
Ibrahim, Ayon
Baca, Luisa G
Kim, Esl
Ghosh, Chandra C
Parikh, Samir M
Jiang, Aihua
Chu, Qingwei
Forman, Daniel E
Lecker, Stewart H
Krishnaiah, Saikumari
Rabinowitz, Joshua D
Weljie, Aalim M
Baur, Joseph A
Kasper, Dennis L
Arany, Zoltan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1805511464
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1805511464
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4057
