Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides
Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides
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Washington, DC: American Association for the Advancement of Science
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English
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Washington, DC: American Association for the Advancement of Science
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It is held as a paradigm that ribosomally synthesized peptides and proteins contain only L-amino acids. We demonstrate a ribosomal origin of the marine sponge—derived polytheonamides, exceptionally potent, giant natural-product toxins. Isolation of the biosynthetic genes from the sponge metagenome revealed a bacterial gene architecture. Only six ca...
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Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides
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TN_cdi_proquest_miscellaneous_1808107419
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808107419
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1226121
