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SAMHD1 prevents autoimmunity by maintaining genome stability

SAMHD1 prevents autoimmunity by maintaining genome stability

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808616877

SAMHD1 prevents autoimmunity by maintaining genome stability

About this item

Full title

SAMHD1 prevents autoimmunity by maintaining genome stability

Publisher

England

Journal title

Annals of the rheumatic diseases, 2015-03, Vol.74 (3), p.e17-e17

Language

English

Formats

Publication information

Publisher

England

More information

Scope and Contents

Contents

The HIV restriction factor, SAMHD1 (SAM domain and HD domain-containing protein 1), is a triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs). Mutations in SAMHD1 cause Aicardi-Goutières syndrome (AGS), an inflammatory disorder that shares phenotypic similarity with systemic lupus erythematosus, including activation of antivi...

Alternative Titles

Full title

SAMHD1 prevents autoimmunity by maintaining genome stability

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1808616877

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808616877

Other Identifiers

ISSN

1468-2060,0003-4967

E-ISSN

1468-2060

DOI

10.1136/annrheumdis-2013-204845

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