A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondro...
A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis
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Publisher
England: Elsevier Limited
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Language
English
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Publisher
England: Elsevier Limited
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ObjectiveTo identify pathogenic mutations that reveal underlying biological mechanisms driving osteoarthritis (OA).MethodsExome sequencing was applied to two distant family members with dominantly inherited early onset primary OA at multiple joint sites with chondrocalcinosis (familial generalised osteoarthritis, FOA). Confirmation of mutations occ...
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A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis
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TN_cdi_proquest_miscellaneous_1808704621
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808704621
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ISSN
0003-4967
E-ISSN
1468-2060
DOI
10.1136/annrheumdis-2013-205149
