Structural analysis of human KDM5B guides histone demethylase inhibitor development
Structural analysis of human KDM5B guides histone demethylase inhibitor development
About this item
Full title
Author / Creator
Johansson, Catrine , Velupillai, Srikannathasan , Tumber, Anthony , Szykowska, Aleksandra , Hookway, Edward S , Nowak, Radoslaw P , Strain-Damerell, Claire , Gileadi, Carina , Philpott, Martin , Burgess-Brown, Nicola , Wu, Na , Kopec, Jola , Nuzzi, Andrea , Steuber, Holger , Egner, Ursula , Badock, Volker , Munro, Shonagh , LaThangue, Nicholas B , Westaway, Sue , Brown, Jack , Athanasou, Nick , Prinjha, Rab , Brennan, Paul E and Oppermann, Udo
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
X-ray crystallographic analyses of KDM5B provide a view of the enzyme's iron(
II
)- and 2-oxoglutarate-containing catalytic core, and structures of KDM5B complexes with small-molecule inhibitors reveal selectivity profiles for multiple compound chemotypes.
Members of the KDM5 (also known as JARID1) family are 2-oxoglutarate- and Fe
2+
Alternative Titles
Full title
Structural analysis of human KDM5B guides histone demethylase inhibitor development
Authors, Artists and Contributors
Author / Creator
Velupillai, Srikannathasan
Tumber, Anthony
Szykowska, Aleksandra
Hookway, Edward S
Nowak, Radoslaw P
Strain-Damerell, Claire
Gileadi, Carina
Philpott, Martin
Burgess-Brown, Nicola
Wu, Na
Kopec, Jola
Nuzzi, Andrea
Steuber, Holger
Egner, Ursula
Badock, Volker
Munro, Shonagh
LaThangue, Nicholas B
Westaway, Sue
Brown, Jack
Athanasou, Nick
Prinjha, Rab
Brennan, Paul E
Oppermann, Udo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1808707942
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808707942
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.2087
