Structural basis for specific inhibition of Autotaxin by a DNA aptamer
Structural basis for specific inhibition of Autotaxin by a DNA aptamer
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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SELEX selections and crystallographic analyses have allowed development of a DNA aptamer that inhibits autotaxin with high potency and specificity, and exhibits efficacy against bleomycin-induced pulmonary fibrosis in model mice.
ATX is a plasma lysophospholipase D that hydrolyzes lysophosphatidylcholine (LPC) and produces lysophosphatidic acid....
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Full title
Structural basis for specific inhibition of Autotaxin by a DNA aptamer
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TN_cdi_proquest_miscellaneous_1808715759
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808715759
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3200
