Allosteric inhibition of antiapoptotic MCL-1
Allosteric inhibition of antiapoptotic MCL-1
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Identification of an allosteric mechanism disrupting the antiapoptotic BH3 binding activity of MCL-1 offers a new approach for targeting the apoptotic resistance of human cancers.
MCL-1 is an antiapoptotic BCL-2 family protein that has emerged as a major pathogenic factor in human cancer. Like BCL-2, MCL-1 bears a surface groove whose function i...
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Full title
Allosteric inhibition of antiapoptotic MCL-1
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TN_cdi_proquest_miscellaneous_1808721830
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808721830
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3223
