Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patie...
Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases
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Author / Creator
Ni, Jing , Ramkissoon, Shakti H , Xie, Shaozhen , Goel, Shom , Stover, Daniel G , Guo, Hanbing , Luu, Victor , Marco, Eugenio , Ramkissoon, Lori A , Kang, Yun Jee , Hayashi, Marika , Nguyen, Quang-De , Ligon, Azra H , Du, Rose , Claus, Elizabeth B , Alexander, Brian M , Yuan, Guo-Cheng , Wang, Zhigang C , Iglehart, J Dirk , Krop, Ian E , Roberts, Thomas M , Winer, Eric P , Lin, Nancy U , Ligon, Keith L and Zhao, Jean J
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
In mouse models of patient-derived breast cancer brain metastases, combined inhibition of PI3K and mTOR resulted in regression, and therapeutic response was correlated with a reduction in 4EBP1 phosphorylation.
Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthoto...
Alternative Titles
Full title
Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases
Authors, Artists and Contributors
Author / Creator
Ramkissoon, Shakti H
Xie, Shaozhen
Goel, Shom
Stover, Daniel G
Guo, Hanbing
Luu, Victor
Marco, Eugenio
Ramkissoon, Lori A
Kang, Yun Jee
Hayashi, Marika
Nguyen, Quang-De
Ligon, Azra H
Du, Rose
Claus, Elizabeth B
Alexander, Brian M
Yuan, Guo-Cheng
Wang, Zhigang C
Iglehart, J Dirk
Krop, Ian E
Roberts, Thomas M
Winer, Eric P
Lin, Nancy U
Ligon, Keith L
Zhao, Jean J
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1808733447
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808733447
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4120
