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7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz...

7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1811889064

7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome

About this item

Full title

7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Pflügers Archiv, 2016-08, Vol.468 (8), p.1403-1418

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

In vitro manipulation of membrane sterol level affects the regulation of ion channels and consequently certain cellular functions; however, a comprehensive study that confirms the pathophysiological significance of these results is missing. The malfunction of 7-dehydrocholesterol (7DHC) reductase in Smith-Lemli-Opitz syndrome (SLOS) leads to the el...

Alternative Titles

Full title

7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1811889064

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1811889064

Other Identifiers

ISSN

0031-6768

E-ISSN

1432-2013

DOI

10.1007/s00424-016-1851-4

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