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Specialized proteasome subunits have an essential role in the thymic selection of CD8 super(+) T cel...

Specialized proteasome subunits have an essential role in the thymic selection of CD8 super(+) T cel...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1811889443

Specialized proteasome subunits have an essential role in the thymic selection of CD8 super(+) T cells

About this item

Full title

Specialized proteasome subunits have an essential role in the thymic selection of CD8 super(+) T cells

Journal title

Nature immunology, 2016-08, Vol.17 (8), p.938-945

Language

English

Formats

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Scope and Contents

Contents

The cells that stimulate positive selection express specialized proteasome beta -subunits different from those expressed by all other cells, including those involved in negative selection. Mice that lack all four specialized proteasome beta -subunits, and therefore express only constitutive proteasomes in all cells, had a profound defect in the gen...

Alternative Titles

Full title

Specialized proteasome subunits have an essential role in the thymic selection of CD8 super(+) T cells

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1811889443

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1811889443

Other Identifiers

ISSN

1529-2908

DOI

10.1038/ni.3480

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