Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse
Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse
About this item
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Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Contents
Rationale
The glutamatergic system plays a key role in the maintenance of drug use and development of drug-related conditioned behaviours. In particular, hyper-glutamatergic activity and N-methyl-D-aspartate receptor (NMDAR) activation may drive drug craving and relapse. Inhibition of kynurenine-3-monooxygenase (KMO) shifts the metabolic kynuren...
Alternative Titles
Full title
Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse
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Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_1815701199
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1815701199
Other Identifiers
ISSN
0033-3158
E-ISSN
1432-2072
DOI
10.1007/s00213-016-4384-9
