Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine...
Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer
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Publisher
United States: National Acad Sciences
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Language
English
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United States: National Acad Sciences
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Contents
Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key modulators of striatal neuronal function. It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an allosteric modulation within the A2AR-D2R heteromer, by which adenosine decreases the affinity and intrinsic efficacy of dopamine a...
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Full title
Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer
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TN_cdi_proquest_miscellaneous_1817826403
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1817826403
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1507704112
