Phosphorylation and structure-based functional studies reveal a positive and a negative role for the...
Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase
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Basingstoke: Nature Publishing
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English
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Basingstoke: Nature Publishing
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c-Abl is a nuclear and cytoplasmic tyrosine kinase involved in a variety of cellular growth and differentiation processes. In contrast to its oncogenic counterparts, like BCR-Abl, c-Abl is not constitutively tyrosine phosphorylated and its catalytic activity is very low. Here we report tyrosine phosphorylation of endogenous c-Abl and a concomitant...
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Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase
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TN_cdi_proquest_miscellaneous_18248468
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_18248468
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1205017
