NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice
NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice
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Publisher
United States: American Association for the Advancement of Science
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Language
English
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Publisher
United States: American Association for the Advancement of Science
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Contents
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD⁺) and its effect on mitochondrial activity as a pivotal switch to modulate muscle SC (MuSC) senescence. Treat...
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Full title
NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice
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TN_cdi_proquest_miscellaneous_1825519354
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1825519354
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaf2693
