Synthetic evolutionary origin of a proofreading reverse transcriptase
Synthetic evolutionary origin of a proofreading reverse transcriptase
About this item
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
Most reverse transcriptase (RT) enzymes belong to a single protein family of ancient evolutionary origin. These polymerases are inherently error prone, owing to their lack of a proofreading (3′- 5′ exonuclease) domain. To determine if the lack of proofreading is a historical coincidence or a functional limitation of reverse transcription, we attemp...
Alternative Titles
Full title
Synthetic evolutionary origin of a proofreading reverse transcriptase
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Record Identifier
TN_cdi_proquest_miscellaneous_1825521795
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1825521795
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaf5409
