Amplification-Mutagenesis: Evidence That "Directed" Adaptive Mutation and General Hypermutability Re...
Amplification-Mutagenesis: Evidence That "Directed" Adaptive Mutation and General Hypermutability Result from Growth with a Selected Gene Amplification
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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When a particular lac mutant of Escherichia coli starves in the presence of lactose, nongrowing cells appear to direct mutations preferentially to sites that allow growth (adaptive mutation). This observation suggested that growth limitation stimulates mutability. Evidence is provided here that this behavior is actually caused by a standard Darwini...
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Amplification-Mutagenesis: Evidence That "Directed" Adaptive Mutation and General Hypermutability Result from Growth with a Selected Gene Amplification
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TN_cdi_proquest_miscellaneous_18259676
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_18259676
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.032680899
