Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis
Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis
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The p53 tumor suppressor protein and the Akt/PKB kinase play important roles in the transduction of pro-apoptotic and anti-apoptotic signals, respectively. We provide evidence that conflicting signals transduced by Akt and p53 are integrated via negative feedback between the two pathways. On the one hand, the combination of ionizing radiation and s...
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Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis
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TN_cdi_proquest_miscellaneous_18307975
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_18307975
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ISSN
0950-9232
DOI
10.1038/sj/onc/1205181
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