Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema
Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema
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Publisher
New York: Springer US
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Language
English
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Publisher
New York: Springer US
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Scope and Contents
Contents
Tie2 is a tyrosine kinase receptor located predominantly on vascular endothelial cells that plays a central role in vascular stability. Angiopoietin-1 (Angpt1), produced by perivascular cells, binds, clusters, and activates Tie2, leading to Tie2 autophosphorylation and downstream signaling. Activated Tie2 increases endothelial cell survival, adhesi...
Alternative Titles
Full title
Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema
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Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_1835634356
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1835634356
Other Identifiers
ISSN
1534-4827
E-ISSN
1539-0829
DOI
10.1007/s11892-016-0816-5
