The interplay between cell signalling and the mevalonate pathway in cancer
The interplay between cell signalling and the mevalonate pathway in cancer
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Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Key Points
Mevalonate (MVA) pathway metabolites are essential for cancer cell survival and growth.
Expression of the genes encoding MVA pathway enzymes is controlled by the sterol regulatory element-binding protein (SREBP) family of transcription factors.
In cancer cells, oncogenic signalling pathways deregulate the activity of the SREBP t...
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Full title
The interplay between cell signalling and the mevalonate pathway in cancer
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TN_cdi_proquest_miscellaneous_1837319101
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1837319101
Other Identifiers
ISSN
1474-175X
E-ISSN
1474-1768
DOI
10.1038/nrc.2016.76
