Targeting mutant p53 through the mevalonate pathway
Targeting mutant p53 through the mevalonate pathway
About this item
Full title
Targeting mutant p53 through the mevalonate pathway
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Nature cell biology, 2016-11, Vol.18 (11), p.1122-1124
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
It is well established that mutant forms of the p53 tumour suppressor acquire pro-oncogenic activities. Inhibition of the mevalonate pathway is now shown to promote degradation of select oncogenic mutant p53 proteins, indicating that destabilization of mutant p53 could be a promising therapeutic strategy.
Alternative Titles
Full title
Targeting mutant p53 through the mevalonate pathway
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1837330434
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1837330434
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3435
