Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the pho...
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF- Kappa B signaling
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Author / Creator
Kuo, M T , Liu, Z , Wei, Y , Lin-Lee, Y-C , Tatebe, S , Mills, G B and Unate, H
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Language
English
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Contents
The expression of P-glycoprotein encoded by the multidrug resistance (MDR1) gene is associated with the emergence of the MDR phenotype in cancer cells. Human MDR1 and its rodent homolog mdr1a and mdr1b are frequently overexpressed in liver cancers. However, the underlying mechanisms are largely unknown. The hepatocarcinogen 2-acetylaminofluorene (2...
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Full title
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF- Kappa B signaling
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TN_cdi_proquest_miscellaneous_18379090
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_18379090
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ISSN
0950-9232
DOI
10.1038/sj/onc/1205117
