Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43...
Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
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Author / Creator
Steinhart, Zachary , Pavlovic, Zvezdan , Chandrashekhar, Megha , Hart, Traver , Wang, Xiaowei , Zhang, Xiaoyu , Robitaille, Mélanie , Brown, Kevin R , Jaksani, Sridevi , Overmeer, René , Boj, Sylvia F , Adams, Jarrett , Pan, James , Clevers, Hans , Sidhu, Sachdev , Moffat, Jason and Angers, Stéphane
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
A genome-wide CRISPR screen reveals that FZD5, but none of the other nine Frizzled receptors encoded in the human genome, is a therapeutic vulnerability of pancreatic and colorectal tumors bearing
RNF43
mutations.
Forward genetic screens with CRISPR–Cas9 genome editing enable high-resolution detection of genetic vulnerabilities in cancer c...
Alternative Titles
Full title
Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
Authors, Artists and Contributors
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Record Identifier
TN_cdi_proquest_miscellaneous_1842549866
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1842549866
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4219
