An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell dea...
An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Sanjay Sinha and colleagues use a vascular model derived from human induced pluripotent stem cells from patients with Marfan syndrome with fibrillin-1 alterations to study aortic aneurysms. They find defects that mimic Marfan pathology as well as novel targets for treatment and can rescue the phenotype by correcting the mutation through genome edit...
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An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death
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TN_cdi_proquest_miscellaneous_1844609270
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1844609270
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3723
