Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
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Author / Creator
Obici, S , Feng, Z , Karkanias, G , Baskin, D G and Rossetti, L
Journal title
Language
English
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Contents
We investigated the role of hypothalamic insulin signaling in the regulation of energy balance and insulin action in rats through selective decreases in insulin receptor expression in discrete hypothalamic nuclei. We generated an antisense oligodeoxynucleotide directed against the insulin receptor precursor protein and administered this directly in...
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Full title
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
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TN_cdi_proquest_miscellaneous_18463604
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_18463604
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ISSN
1097-6256
DOI
10.1038/nn861
