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Small-molecule factor D inhibitors targeting the alternative complement pathway

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Small-molecule factor D inhibitors targeting the alternative complement pathway

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1846402893

Small-molecule factor D inhibitors targeting the alternative complement pathway

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Publisher

New York: Nature Publishing Group US

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Contents

A fragment-based design approach identifies reversible inhibitors targeting human protease complement factor D (FD), which is required for amplification of complement C3 signaling. FD inhibitors act as systemic regulators of complement activation
in vivo
.
Complement is a key component of the innate immune system, recognizing pathogens and...

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Full title

Small-molecule factor D inhibitors targeting the alternative complement pathway

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Record Identifier

TN_cdi_proquest_miscellaneous_1846402893

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1846402893

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ISSN

1552-4450

E-ISSN

1552-4469

DOI

10.1038/nchembio.2208

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