MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis
MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Microglial cells in the brain tumor microenvironment are associated with enhanced glioma malignancy. They persist in an immunosuppressive M2 state at the peritumoral site and promote the growth of gliomas. Here, we investigated the underlying factors contributing to the abolished immune surveillance. We show that brain tumors escape pro-inflammator...
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Full title
MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis
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TN_cdi_proquest_miscellaneous_1850773813
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1850773813
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2016.160
