Cryo-EM structure of a human spliceosome activated for step 2 of splicing
Cryo-EM structure of a human spliceosome activated for step 2 of splicing
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Spliceosome rearrangements facilitated by RNA helicase PRP16 before catalytic step two of splicing are poorly understood. Here we report a 3D cryo-electron microscopy structure of the human spliceosomal C complex stalled directly after PRP16 action (C*). The architecture of the catalytic U2–U6 ribonucleoprotein (RNP) core of the human C* spliceosom...
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Full title
Cryo-EM structure of a human spliceosome activated for step 2 of splicing
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TN_cdi_proquest_miscellaneous_1858109861
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1858109861
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature21079
